Antihypertensive Effects of the Putative T-Type Calcium Channel Antagonist Mibefradil Are Mediated by the L-Type Calcium Channel Ca v 1.2
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چکیده
منابع مشابه
Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.
The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca2+ channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, time- and tissue-specific conditional knockout model of the L-type Ca2+ chann...
متن کاملAntihypertensive Effects of the Putative T-Type Calcium Channel Antagonist Mibefradil
The role of T-type Ca channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, timeand tissue-specific conditional knockout model of the L-type Ca channel Cav1....
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000197851.11031.9c